NSC194598
Product Specifications
CAS Number
5358-76-9
Target
C-RET|||Others
Related Pathways
Tyrosine Kinase/Adaptors|||Apoptosis|||Others
Bioactivity
NSC194598, a p53 DNA-binding inhibitor, demonstrates an in vitro IC50 of 180 nM and an in vivo range of 2-40 ?M. It disrupts the transcriptional activation of the mutated RET gene in human medullary thyroid carcinoma TT cells and is utilized in research investigating acute toxicity in normal tissues due to radiation and chemotherapy [1] [2].
Smiles
O=N=1C(=NC2=CC=CC=3C=4C=CC=CC4C1C23)CN5CCCCC5
Molecular Formula
C20H19N3O
Molecular Weight
317.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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