ERK1/2 inhibitor 9
Product Specifications
CAS Number
2169302-75-2
Target
ERK
Related Pathways
MAPK
Bioactivity
ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates the reduction of phospho-ERK1/2 levels. When conjugated with trans-cyclo-octene (TCO) and Tz-Thalidomide (tetrazine-tagged Thalidomide), it forms the corresponding ERK-CLIPTAC, promoting targeted ERK1/2 degradation [1].
Smiles
O=C(OC1CCC=CCCC1)NCCC#CC2=NC=CC(=C2)NC3=NC=C(Cl)C(=N3)NC=4C=CC=CC4NC(=O)C=C
Molecular Formula
C31H32ClN7O3
Molecular Weight
586.08
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
E45M19373V-2 50 µL
ST2 (IL1RL1) Mouse Monoclonal Antibody [Clone 2F1]
Sign In for Pricing
View Details