MitoCur-1

MitoCur-1, a curcumin analogue, inhibits the mitochondrial antioxidative enzyme thioredoxin reductase 2 (TrxR2) and possesses electrophilic characteristics with mitochondrial-targeting capabilities. This compound specifically induces reactive oxygen species (ROS) generation, demonstrating antitumor efficacy [1].

COC1=C(OCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C=CC(/C=C/C(C(C)(C)C(/C=C/C5=CC=C(OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)C(OC)=C5)=O)=O)=C1.[Cl-].[Cl-]