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Dothiepin

Product Specifications

CAS Number

113-53-1

Target

5-HT Receptor, Histamine Receptor

Related Pathways

Neuroscience, Immunology/Inflammation, GPCR/G Protein

Bioactivity

Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancing noradrenergic neurotransmission by blocking neuronal reuptake. Additionally, it acts as a histamine H1-receptor antagonist and lacks cardiotoxicity. Its analgesic efficacy is noted in conditions such as psychogenic facial pain, idiopathic fibromyalgia syndrome, and rheumatoid arthritis [1].

Smiles

S1C=2C=CC=CC2C(=CCCN(C)C)C=3C=CC=CC3C1

Molecular Formula

C19H21NS

Molecular Weight

295.44

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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