Dothiepin
Product Specifications
CAS Number
113-53-1
Target
5-HT Receptor|||Histamine Receptor
Related Pathways
Neuroscience|||Immunology/Inflammation|||GPCR/G Protein
Bioactivity
Dothiepin (Dosulepin; Dothep), an antidepressant with sedative/anxiolytic properties, preferentially inhibits noradrenaline over serotonin uptake, enhancing noradrenergic neurotransmission by blocking neuronal reuptake. Additionally, it acts as a histamine H1-receptor antagonist and lacks cardiotoxicity. Its analgesic efficacy is noted in conditions such as psychogenic facial pain, idiopathic fibromyalgia syndrome, and rheumatoid arthritis [1].
Smiles
S1C=2C=CC=CC2C(=CCCN(C)C)C=3C=CC=CC3C1
Molecular Formula
C19H21NS
Molecular Weight
295.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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