PAMP-12 (unmodified) acetate

Product Specifications

Target

Others|||Adrenergic Receptor

Related Pathways

Neuroscience|||GPCR/G Protein|||Others

Purity

0.9897

Bioactivity

PAMP-12 (unmodified) acetate is an endogenous peptide and potent agonist of the MRGPRX2 (MrgX2) receptor with an EC50 ranging from 20 to 50 nM. PAMP-12 (unmodified) mediates hypotensive effects by inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells, serving as a critical tool in the study of neuroimmune interactions and cardiovascular regulation.

Smiles

N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O.CC(O)=O