Tagarafdeg
Product Specifications
CAS Number
2882165-79-7
Target
PROTACs, Raf
Related Pathways
MAPK, PROTAC
Purity
>99.99%
Bioactivity
Tagarafdeg (CFT1946) is an orally available PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E (Class I), G469A (Class II), G466V (type III) mutations, and the p61-BRAF V600E splice variant. It exhibits favourable selectivity within the proteome, including for wild-type BRAF and CRAF, and inhibits tumour cell proliferation.
Smiles
CN1C=2C(C(=N1)N3C(=O)NC(=O)CC3)=CC(F)=C(C2)N4CCC(CC(=O)N5CCC6(CC5)C[C@H](CO6)N7C(=O)C=8C(N=C7)=CC=C(OC9=C(C#N)C(NS(N(CC)C)(=O)=O)=CC=C9F)C8)(O)CC4
Molecular Formula
C45H49F2N11O9S
Molecular Weight
958
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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