BSJ-03-204 triTFA
Product Specifications
Target
PROTACs, CDK
Related Pathways
PROTAC, Cell Cycle/Checkpoint
Bioactivity
BSJ-03-204 triTFA is a potent and selective Cereblon- and CDK-targeted PROTAC (PROteolysis TArgeting Chimera) featuring Palbociclib-based ligands for the degradation of CDK4/6. It exhibits IC50 values of 26.9 nM for CDK4/D1 and 10.4 nM for CDK6/D1, indicating strong inhibitory capabilities. Notably, it spares IKZF1/3 from degradation and possesses anti-cancer activity [1].
Molecular Formula
C49H51F9N10O14
Molecular Weight
1174.97
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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