(Aminooxy) acetamide-Val-Cit-PAB-MMAE
Product Specifications
CAS Number
2446645-88-9
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
(Aminooxy) acetamide-Val-Cit-PAB-MMAE (MMAE 5) serves as an intermediate for synthesizing drug-linker conjugates in antibody-drug conjugates (ADCs) . The compound is initially conjugated to a polyamide via oxime bond formation, forming an MMAE polyamide conjugate, which is then attached to Trastuzumab to create the ADC [1].
Smiles
[C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OCC3=CC=C(NC([C@@H](NC([C@@H](NC(CON)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C=C3)=O)C)C(C)C)=O)[C@@H](C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
Molecular Formula
C60H97N11O14
Molecular Weight
1196.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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