ROS-generating agent 1
Product Specifications
CAS Number
2369030-41-9
Target
Reactive Oxygen Species|||Ferroptosis|||Apoptosis|||ROS Kinase|||ROS
Related Pathways
Immunology/Inflammation|||NF-?B|||Tyrosine Kinase/Adaptors|||Apoptosis|||Metabolism
Purity
0.9976
Bioactivity
Ros-generating agent 1 has anticancer activity and generates ROS by covalently modifying Sec-498 residues of TrxR. ROS-generating agent 1 reduces intracellular TrxR protein levels and promotes ROs-dependent apoptosis and ferroptosis in NCI-H460 cells.
Smiles
C(=C\1/C(=O)\C(=C\C2=CC(C(F)(F)F)=CC=C2)\CNC1)\C3=CC(C(F)(F)F)=CC=C3
Molecular Formula
C21H15F6NO
Molecular Weight
411.34
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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