BML-278
Product Specifications
CAS Number
120533-76-8
Target
Histone Methyltransferase, Sirtuin
Related Pathways
DNA Damage/DNA Repair, Chromatin/Epigenetic
Purity
>99.99%
Bioactivity
BML-278 is a SIRT1 activator with an EC150 of 1 μM. It increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, improving early embryonic development. BML-278 induces cell cycle arrest at the G1/S phase in primary human mesenchymal stromal cells, delaying senescence. It also reduces microtubule protein acetylation in U937 cells and increases mitochondrial density in mouse C2C12 myoblasts.
Smiles
CCOC(=O)C1=CN(Cc2ccccc2)C=C(C1c1ccccc1)C(=O)OCC
Molecular Formula
C24H25NO4
Molecular Weight
391.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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