Multi-kinase-IN-5

Multi-kinase-IN-5 (compound 15c) is a multi-kinase inhibitory agent that demonstrates significant inhibition of a range of protein kinases, including RET (69%), KIT (31%), cMet (62%), VEGFR1 (40%), VEGFR2 (73%), FGFR1 (74%), PDGFR (59%), and BRAF (74%) . Its IC50 values are 1.287 ?M for FGFR1, 0.117 ?M for VEGFR, and 1.185 ?M for RET kinases, indicating its potency [1].