JC2-11
Product Specifications
CAS Number
937820-89-8
Target
NOD-like Receptor (NLR) |||AIM2|||IL Receptor|||Caspase|||Dehydrogenase|||ROS
Related Pathways
Immunology/Inflammation|||Metabolism|||Apoptosis|||Proteases/Proteasome
Purity
0.9988
Bioactivity
JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1? and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1? and lactate dehydrogenase (LDH) release from inflammatory vesicles.
Smiles
C(/C=C/C1=CC(OC)=C(O)C=C1)(=O)C2=CC(F)=C(OC)C=C2
Molecular Formula
C17H15FO4
Molecular Weight
302.3
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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