AOH1996
Product Specifications
CAS Number
2089314-64-5
Target
DNA, Apoptosis
Related Pathways
DNA Damage/DNA Repair, Apoptosis
Purity
0.9962
Bioactivity
AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC) . It interferes with the interaction of PCNA with its binding proteins, leading to DNA replication stress and apoptosis. AOH1996 causes proteasome-dependent rpb1 degradation and lethal DNA damage by stabilizing the interaction between PCNA and RNA polymerase II, and acts synergistically with DNA damaging agents to inhibit tumor cell growth.
Smiles
C(NCC(NC1=C(OC2=CC(OC)=CC=C2)C=CC=C1)=O)(=O)C=3C4=C(C=CC3)C=CC=C4
Molecular Formula
C26H22N2O4
Molecular Weight
426.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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