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HDAC-IN-57

Product Specifications

CAS Number

2716217-79-5

Target

Apoptosis, HDAC

Related Pathways

Chromatin/Epigenetic, DNA Damage/DNA Repair, Apoptosis

Purity

0.9862

Bioactivity

HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4 nM, and 107 nM, respectively. HDAC-IN-57 inhibits LSD1 with an IC50 value of 1.34 μΜ. HDAC-IN-57 has anti-tumor activity and can induce apoptosis.

Smiles

C(NCC1=CC=C(C(NO)=O)C=C1)(=O)C=2C=C(N=CC2)C3=CC=C(OC)C=C3

Molecular Formula

C21H19N3O4

Molecular Weight

377.39

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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