Crovalimab

Product Specifications

CAS Number

1917321-26-6

Target

Complement System

Related Pathways

Immunology/Inflammation

Purity

0.9968

Bioactivity

Crovalimab (SKY59; RO7112689) is an Fc-engineered and pH-dependent humanised monoclonal antibody that binds to complement C5 and blocks its cleavage into C5a and C5b, thereby inhibiting MAC formation and intravascular haemolysis. It can rebind to the FcRn receptor under acidic pH conditions and return to the bloodstream, making it suitable for the treatment of paroxysmal nocturnal haemoglobinuria (PNH) .