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Elezanumab

Product Specifications

CAS Number

1791416-49-3

Target

RGM, TGF-beta/Smad

Related Pathways

Neuroscience, Stem Cells

Purity

0.987

Bioactivity

Elezanumab (ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, with an IC50 of approximately 97 pM.Elezanumab promotes neuroregeneration, neuroprotection, and neural restoration in models of neuronal injury and demyelination. Elezanumab promotes the growth of corticospinal axons into spinal gray matter and enhances serotonergic innervation in the ventral horn, forming synaptic connections in the caudal part of cervical lesions.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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