Seribantumab
Product Specifications
CAS Number
1334296-12-6
Target
EGFR, HER, Apoptosis
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis, JAK/STAT signaling
Purity
0.9626
Bioactivity
Seribantumab (MM 121) is a humanized monoclonal antibody targeting HER3, inhibiting NRG1-induced growth in MCF-7 cells and patient-derived breast and lung cancer cells harboring NRG1 fusions or amplifications. It also induces apoptosis in MDA-MB-175-VII and LUAD-0061AS3 cells.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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