Teprotumumab
Product Specifications
CAS Number
1036734-93-6
Target
IGF-1R, TSH Receptor
Related Pathways
Tyrosine Kinase/Adaptors, GPCR/G Protein
Purity
0.996
Bioactivity
Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R) . Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab reduces TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used in the study of thyroid-associated eye diseases.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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