HMC1R agonist 1

HMC1R agonist 1, with an EC 50 of 3 nM, exhibits at least 300-fold higher selectivity for hMC1R compared to hMC3R (EC 50 >902 nM), hMC4R (EC 50 >915 nM), and hMC5R (EC 50 >1000 nM) . This compound demonstrates potential for therapeutic applications in targeting the melanocortin family [1].