Coibamide A
Product Specifications
CAS Number
1029227-48-2
Target
Autophagy, Apoptosis, VEGFR
Related Pathways
Tyrosine Kinase/Adaptors, Autophagy, Apoptosis, Angiogenesis
Bioactivity
Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, exhibits potent antiproliferative activity, induces autophagosome accumulation via an mTOR-independent mechanism, and triggers apoptosis. Furthermore, it inhibits VEGFA/VEGFR2 expression, effectively suppressing tumor growth in glioblastoma xenografts [1] [2].
Smiles
[H][C@@]1([C@@H](C)CC)N(C)C(=O)[C@H](COC)N(C)C(=O)[C@H]([C@@H](C)OC(=O)[C@@H](C)N(C)C(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C)NC1=O)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](COC)N(C)C(=O)[C@H](OC(=O)[C@H](C(C)C)N(C)C)C(C)C
Molecular Formula
C65H110N10O16
Molecular Weight
1287.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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