(Glu2) -TRH
Product Specifications
CAS Number
85541-78-2
Target
Thyroid hormone receptor (THR), Endogenous Metabolite
Related Pathways
Metabolism, Endocrinology/Hormones
Bioactivity
(Glu2) -TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH), acts as a negative modulator of TRH's cholinergic effect in the mouse brain, significantly reducing TRH-induced release of extracellular acetylcholine in the hippocampus. Resistant to metabolism by thyroliberinase, (Glu2) -TRH exhibits neuroprotective, antidepressant, and anticonvulsant properties in the CNS [1].
Smiles
NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCC(=O)N1
Molecular Formula
C15H22N4O6
Molecular Weight
354.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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