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(Glu2) -TRH

Product Specifications

CAS Number

85541-78-2

Target

Thyroid hormone receptor (THR), Endogenous Metabolite

Related Pathways

Metabolism, Endocrinology/Hormones

Bioactivity

(Glu2) -TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH), acts as a negative modulator of TRH's cholinergic effect in the mouse brain, significantly reducing TRH-induced release of extracellular acetylcholine in the hippocampus. Resistant to metabolism by thyroliberinase, (Glu2) -TRH exhibits neuroprotective, antidepressant, and anticonvulsant properties in the CNS [1].

Smiles

NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCC(=O)N1

Molecular Formula

C15H22N4O6

Molecular Weight

354.36

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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