Amyloid 17-42

Amyloid 17-42 (Aβ (17-42) ), a significant component of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, results from alpha- and gamma-secretase cleavage of amyloid precursor protein (APP) and can trigger neuronal apoptosis via the Fas-like/caspase-8 activation pathway [1].

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