C[Arg-Arg-Arg-Arg-Dip-Dip-Dip]

Compound 8C (c[Arg-Arg-Arg-Arg-Dip-Dip-Dip]) demonstrates broad-spectrum efficacy against drug-resistant Gram-positive and Gram-negative bacteria. Specifically, it exhibits minimum inhibitory concentrations (MICs) of 3.1 μg/mL for MRSA (ATCC BAA-1556), 3.1 μg/mL for S. aureus (ATCC 29213), 12.5 μg/mL for P. aeruginosa (ATCC 27883), and 12.5 μg/mL for E. coli (ATCC 25922) [1].

[C@H]([C@H]1C(=O)N[C@@H]([C@@H](C2=CC=CC=C2)C3=CC=CC=C3)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@@H]([C@H](C4=CC=CC=C4)C5=CC=CC=C5)C(=O)N1)(C6=CC=CC=C6)C7=CC=CC=C7