NH2-c[X-R-L-S-X]-K-G-P- (D-1Nal)

Compound 39 (NH2-c[X-R-L-S-X]-K-G-P- (D-1Nal) ) is a potent agonist of the APJ receptor, possessing a K i value of 0.6 nM. It is capable of activating Gαi1, with an EC 50 of 0.8 nM, and of recruiting β-arrestin2, with an EC 50 of 31 nM. Furthermore, this compound demonstrates extended effects on cardiac function [1].