HXR9 hydrochloride
Product Specifications
Target
Apoptosis
Related Pathways
Apoptosis
Bioactivity
HXR9 hydrochloride, a cell-permeable peptide and competitive antagonist of the HOX/PBX interaction, selectively reduces cell proliferation and induces apoptosis in cells with elevated HOXA/PBX3 gene expression, notably MLL-rearranged leukemic cells [1] [2] [3]. By inhibiting the interaction between HOX proteins and the transcription factor PBX, which associates with HOX proteins in paralogue groups 1 to 8, it disrupts a critical regulatory mechanism in these cells.
Molecular Formula
C119H194ClN53O20S
Molecular Weight
2754.67
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/64416192206471190/T76213
Available Sizes
Curated Selection
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