3α-Hydroxysteroid dehydrogenase

3?-Hydroxysteroid dehydrogenase (3?-HSD), encoded by the AKR1C4 gene, is responsible for catalyzing the transformation of 3-ketosteroids into 3?-hydroxy compounds. This enzyme significantly contributes to the inactivation of the androgen DHT by converting it into 3?-androstanediol, which exhibits reduced androgen activity. Such conversions are crucial in hirsutism research [1].