Spadin TFA
Product Specifications
Target
5-HT Receptor, Potassium Channel
Related Pathways
GPCR/G Protein, Neuroscience, Membrane transporter/Ion channel
Bioactivity
Spadin TFA, a natural peptide originating from a propeptide in blood, acts as a powerful TREK-1 channel inhibitor with an IC 50 of 10 nM. It boosts dorsal raphe nucleus 5-HT neurotransmission in mice, activates hippocampal CREB, and promotes neurogenesis. This compound is useful for antidepressant research [1] [2].
Molecular Formula
C92H143F3N26O24
Molecular Weight
2126.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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