Decapeptide-12

Decapeptide-12, a competitive inhibitor of mushroom tyrosinase with an IC50 of 40 μM and a Kd of 61.1 μM for the C-terminal residue of tyrosinase, is a small oligopeptide that reduces melanin content in melanocytes by interacting with tyrosinase and increasing transcription of SIRT. It is utilized in researching melanogenesis, senescence, and inflammation [1] [2] [3].

C([C@@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(O)=O)=O)NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=C(O)C=C3)N)=O)CCCNC(=N)N)=O)CO)=O)CCCNC(=N)N)=O)CCCCN)=O)=O)CO)=O)CO)=O)C=4C=5C(NC4)=CC=CC5