Himastatin

Himastatin, a dimeric cyclohexadepsipeptide featuring piperazic acid and a distinctive central aromatic core [1], is an antitumor antibiotic synthesized by a strain of S. hygroscopicus sp.

O[C@]12[C@](N3[C@@](C1)(C(=O)N[C@H]([C@H](C)C)C(=O)O[C@@H](C(C)C)C(=O)N4[C@@](C(=O)N[C@@H](CC(C)C)C(=O)N[C@]([C@H](C)O)(C3=O)[H])(C[C@@H](O)CN4)[H])[H])(NC=5C2=CC(=CC5)C=6C=C7[C@@]8(O)[C@@](NC7=CC6)(N9[C@@](C8)(C(=O)N[C@H]([C@@H](C)C)C(=O)O[C@@H](C(C)C)C(=O)N%10[C@@](C(=O)N[C@@H](CC(C)C)C(=O)N[C@]([C@H](C)O)(C9=O)[H])(C[C@@H](O)CN%10)[H])[H])[H])[H]