Secalonic acid D
Product Specifications
CAS Number
35287-69-5
Target
C-Myc, Apoptosis, GSK-3, Others, Wnt/beta-catenin
Related Pathways
Others, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint, Stem Cells, Cytoskeletal Signaling, Apoptosis
Bioactivity
Secalonic acid D, a toxic compound effective against tumor cells, is derived from the metabolites of Aspergillus aculeatus. It operates by activating GSK3-β and degrading β-catenin, consequently down-regulating c-Myc expression, arresting the cell cycle at the G1 phase, and inducing cell apoptosis [1] [2].
Smiles
C(OC)(=O)[C@]12C(C(=O)C=3C(O1)=CC=C(C3O)C=4C(O)=C5C(=CC4)O[C@]6(C(OC)=O)C(C5=O)=C(O)C[C@H](C)[C@H]6O)=C(O)C[C@H](C)[C@H]2O
Molecular Formula
C32H30O14
Molecular Weight
638.57
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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