Alpha-1,4-Galactosyltransferase (LgtC)

Alpha-1,4-Galactosyltransferase (LgtC) (A4GALT), a glycosphingolipid-specific glycosyltransferase, catalyzes the transfer of a galactose molecule to the alpha-1,4 position on lactosylceramide, resulting in the formation of globotriaosylceramide. This enzyme plays a crucial role in the synthesis of P1 blood group antigens [1] [2].