Canfosfamide
Product Specifications
CAS Number
158382-37-7
Target
Others, Apoptosis, DNA-PK
Related Pathways
Apoptosis, DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling, Others
Bioactivity
Canfosfamide (TLK-286, TER286), a glutathione analogue prodrug, becomes activated by glutathione S-transferase P1-1 to induce apoptosis and inhibit DNA-dependent protein kinase's (DNA-PK) catalytic kinase activity. Upon activation, it generates an anticancer alkylating agent and a glutathione derivative, making it useful in researching malignancies [1] [2] [3].
Smiles
P(N(CCCl)CCCl)(N(CCCl)CCCl)(OCCS(C[C@@H](C(N[C@@H](C(O)=O)C1=CC=CC=C1)=O)NC(CC[C@@H](C(O)=O)N)=O)(=O)=O)=O
Molecular Formula
C26H40Cl4N5O10PS
Molecular Weight
787.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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