Taltobulin hydrochloride
Product Specifications
Target
Apoptosis, ADC Cytotoxin, Microtubule Associated
Related Pathways
Cytoskeletal Signaling, Apoptosis, Antibody-drug Conjugate/ADC Related
Bioactivity
Taltobulin hydrochloride (HTI-286 hydrochloride), a synthetic analogue of the tripeptide hemiasterlin, effectively bypasses P-glycoprotein-mediated resistance both in vitro and in vivo as a robust antimicrotubule agent. It prevents the polymerization of purified tubulin, destabilizes cellular microtubule structures, and triggers both mitotic arrest and apoptosis [1].
Molecular Formula
C27H44ClN3O4
Molecular Weight
510.11
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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