ARC19499
Product Specifications
CAS Number
1350667-54-7
Target
Others|||Factor VIIa|||Factor Xa
Related Pathways
Metabolism|||Others
Bioactivity
ARC19499, an aptamer, inhibits the tissue factor pathway inhibitor (TFPI), facilitating clot initiation and propagation through the extrinsic pathway. It binds specifically to TFPI, blocking its inhibition of both factor Xa and the TF/factor VIIa complex, thereby correcting thrombin generation in hemophilia A and B plasma and restoring clotting in FVIII-neutralized whole blood.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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