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ARC19499

Product Specifications

Target

Others|||Factor VIIa|||Factor Xa

Related Pathways

Metabolism|||Others

Bioactivity

ARC19499, an aptamer, inhibits the tissue factor pathway inhibitor (TFPI), facilitating clot initiation and propagation through the extrinsic pathway. It binds specifically to TFPI, blocking its inhibition of both factor Xa and the TF/factor VIIa complex, thereby correcting thrombin generation in hemophilia A and B plasma and restoring clotting in FVIII-neutralized whole blood.

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Product Datasheet

https://www.targetmol.com/attachment/DataSheet/64416115505233984/T75152

CAS Number

1350667-54-7

Available Sizes

Curated Selection

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