Zomiradomide
Product Specifications
CAS Number
2655656-99-6
Target
IKZF, IRAK, NF-κB, PROTACs, IFNAR
Related Pathways
PROTAC, Immunology/Inflammation, NF-κB
Purity
0.9841
Bioactivity
Zomiradomide is a PROTAC degradation agent targeting IRAK4, with oral bioavailability, and can also degrade Ikaros (IKZF1) and Aiolos (IKZF3), thereby inhibiting the NF-κB signalling pathway and activating the type I interferon signalling pathway, exhibiting anticancer activity against B-cell lymphoma.
Smiles
C(N1CC2(C1)CC(CCNC3=C4C(C(=O)N(C4=O)C5C(=O)NC(=O)CC5)=CC=C3)C2)[C@H]6CC[C@@H](CC6)C=7SC=8C(N7)=CC(C(C)(C)O)=C(NC(=O)C=9N=C(C(F)(F)F)C=CC9)C8
Molecular Formula
C45H48F3N7O6S
Molecular Weight
871.97
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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