NX-5948
Product Specifications
CAS Number
2649400-34-8
Target
PROTACs|||BTK
Related Pathways
PROTAC|||Tyrosine Kinase/Adaptors|||Angiogenesis
Purity
0.9829
Bioactivity
NX-5948 (BTK-IN-24) is an orally bioavailable and blood-brain barrier-penetrable PROTAC BTK degrader with anti-inflammatory and antitumor activities. It induces BTK protein degradation via the cereblon E3 ligase complex, inhibiting B cell activation.
Smiles
N(C=1N=C(C=NC1C(N)=O)N2C[C@@H](CCC2)N3C(=O)N(C)CC3)C4=CC=C(C=C4)C5CCN(CC6CCN(CC6)C=7C=CC(C(N[C@@H]8C(=O)NC(=O)CC8)=O)=NC7)CC5
Molecular Formula
C42H54N12O5
Molecular Weight
806.96
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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