Nampt degrader-2
Product Specifications
Target
PROTACs|||NAMPT|||Others
Related Pathways
Metabolism|||PROTAC|||Others
Bioactivity
Nampt degrader-2, a fluorescent PROTAC, exhibits efficient degradation of NAMPT at an IC50 of 41.9 nM. It operates by binding to both NAMPT and VHL, initiating the formation of a ternary complex that triggers NAMPT degradation through the ubiquitin-proteasome system (UPS) . This activity significantly lowers NAD+ levels and displays potent antitumor effects [1].
Molecular Formula
C59H73N9O7S
Molecular Weight
1052.33
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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