HDAC6 degrader-3
Product Specifications
CAS Number
2785404-83-1
Target
PROTACs, HDAC
Related Pathways
PROTAC, Chromatin/Epigenetic, DNA Damage/DNA Repair
Bioactivity
HDAC6 degrader-3, a selective and potent degrader of HDAC6 through ternary complex formation and the ubiquitin-proteasome pathway, exhibits a DC50 value of 19.4 nM. With IC50 values of 4.54 nM for HDAC6 and 0.647 μM for HDAC1, it effectively induces robust hyperacetylation of α-tubulin [1].
Smiles
C(C(O)=O)(F)(F)F.O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCCCCCCC(NC=4C=C5C(=CC4)N(CC6=C(F)C=C(C(NO)=O)C=C6)C(C)=N5)=O)=O
Molecular Formula
C41H41F4N7O11
Molecular Weight
883.8
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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