PROTAC HDAC6 degrader 1

Product Specifications

CAS Number

2785404-76-2

Target

HDAC|||Others|||Apoptosis|||PROTACs

Related Pathways

Apoptosis|||Others|||DNA Damage/DNA Repair|||Chromatin/Epigenetic|||PROTAC

Bioactivity

Compound A6, a potent and selective PROTAC HDAC6 degrader, exhibits a DC50 of 3.5 nM. It demonstrates notable antiproliferative activity by inducing apoptosis in myeloid leukemia cell lines [1].

Smiles

O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2OCC(NCCCCCCCC(NC4=CC=C(C(NCCCCCCC(NO)=O)=O)C=C4)=O)=O

Molecular Formula

C37H46N6O10

Molecular Weight

734.8

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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