FXR agonist 3
Product Specifications
Target
FXR, Others
Related Pathways
Metabolism, Others
Purity
0.9504
Bioactivity
FXR agonist 3 is an anti-NASH compound with antifibrotic and anti-fibrotic activity, inhibiting the expression of COL1A1, TGF-β1, α-SMA, and TIMP1, with an IC50 value of 8.19 μmol/L for COL1A1. FXR agonist 3 ameliorates CDAHFD and BDL-induced liver injury in vivo by activating FXR.
Smiles
COC1=CC2=C(C=C1OC)CC[N+]3=C2C=C4C(C(OCC5=CC=CC(C)=C5)=C(OC)C=C4)=C3.[Br-]
Molecular Formula
C28H28BrNO4
Molecular Weight
521.12
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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