SJ988497
Product Specifications
CAS Number
2595365-41-4
Target
JAK, PROTACs
Related Pathways
Angiogenesis, Stem Cells, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, PROTAC, JAK/STAT signaling
Bioactivity
SJ988497 is a PROTAC JAK2 degrader that effectively inhibits proliferation in CRLF2-rearranged (CRLF2r) cells and facilitates the degradation of the CRBN neosubstrate GSPT1. Composed of a Ruxolitinib derivative, a linker, and the CRBN ligand Pomalidomide, SJ988497 is utilized in researching acute lymphoblastic leukemia (ALL) [1].
Smiles
O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCCCNC(=O)C4=CC=C(NC5=NC(=C6C(=N5)NC=C6)C7=CN(CCC)N=C7)C=C4
Molecular Formula
C36H36N10O5
Molecular Weight
688.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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