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SJ988497

Product Specifications

CAS Number

2595365-41-4

Target

JAK|||PROTACs

Related Pathways

Angiogenesis|||Stem Cells|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||PROTAC|||JAK/STAT signaling

Bioactivity

SJ988497 is a PROTAC JAK2 degrader that effectively inhibits proliferation in CRLF2-rearranged (CRLF2r) cells and facilitates the degradation of the CRBN neosubstrate GSPT1. Composed of a Ruxolitinib derivative, a linker, and the CRBN ligand Pomalidomide, SJ988497 is utilized in researching acute lymphoblastic leukemia (ALL) [1].

Smiles

O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCCCNC(=O)C4=CC=C(NC5=NC(=C6C(=N5)NC=C6)C7=CN(CCC)N=C7)C=C4

Molecular Formula

C36H36N10O5

Molecular Weight

688.74

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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