ACBI2
Product Specifications
CAS Number
2913161-19-8
Target
Epigenetic Reader Domain, PROTACs
Related Pathways
PROTAC, Chromatin/Epigenetic
Bioactivity
ACBI2, an orally active and highly potent VHL PROTAC (EC 50: 7 nM), selectively degrades SMARCA2, demonstrating a DC 50 value of 1 nM in RKO cells. This compound holds potential for lung cancer research [1].
Smiles
O=C1N=C2N(C=3C(N2C4CCCC4)=CC(=CC3)C5CCN(CC[C@H](CC[C@H](NC(=O)[C@H]6N(C([C@@H](NC(=O)C7(F)CC7)C(C)(C)C)=O)C[C@H](O)C6)C8=CC=C(C=C8)C9=C(C)N=CS9)C)CC5)C=%10C1=C(Br)C=CC%10
Molecular Formula
C56H68BrFN8O5S
Molecular Weight
1064.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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