Phytoene desaturase-IN-1

Phytoene desaturase-IN-1, a potent inhibitor of phytoene desaturase (PDS) with a dissociation constant (Kd) of 65.9 μM, acts through π−π stacking interaction with the Phe301 residue. This compound exhibits a broad spectrum of post-emergence herbicidal effects by inducing a reduction in PDS mRNA, and accumulation of phytoene and reactive oxygen species (ROS) in albino leaves, suggesting its utility in agricultural production [1].