Cys-McMMAF

Product Specifications

CAS Number

1160590-05-5

Target

Microtubule Associated|||Others

Related Pathways

Cytoskeletal Signaling|||Others

Bioactivity

Cys-McMMAF, the active compound liberated from AlMcMMAF—a humanized anti-5T4 A1 antibody connected to the microtubule-disrupting molecule MMAF through a maleimidocaproyl linker—demonstrates antitumor effectiveness in two mouse tumor models (H1975 and MDA-MB-361-DYT2) [1].

Smiles

[H][C@]1(CCCN1C(=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCCN1C(=O)CC(SC[C@H](N)C(O)=O)C1=O)C(C)C)[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O