YL5084
Product Specifications
CAS Number
2440199-73-3
Target
Others, Apoptosis, JNK
Related Pathways
MAPK, Apoptosis, Others
Bioactivity
YL5084, a covalent inhibitor selective for JNK2 and JNK3 over JNK1, demonstrates IC50 values of 70 nM and 84 nM for JNK2 and JNK3, respectively, compared to 2173 nM for JNK1. This compound also shows antiproliferative effects and induces apoptosis independently of JNK2 activity [1].
Smiles
N(C=1N=C(C=2C(=NN3C2C=CC=C3)C4=CC=CC=C4)C=CN1)[C@@H]5CN(C(=O)C6=CC=C(NC(/C=C/CN(C)C)=O)C=C6)C[C@@H]5C
Molecular Formula
C35H36N8O2
Molecular Weight
600.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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