ITK degrader 1
Product Specifications
Target
Others, PROTACs, Tyrosine Kinases
Related Pathways
Tyrosine Kinase/Adaptors, PROTAC, Others
Bioactivity
ITK Degrader 1, a highly selective interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice) degrader, induces rapid and prolonged degradation of ITK and effectively suppresses IL-2 secretion (EC50=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibody in vivo. Additionally, it demonstrates favorable plasma exposure levels [1].
Molecular Formula
C48H57F3N10O7
Molecular Weight
943.02
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6401826-01 0.1 mL
Prostein (Solute Carrier Family 45 Member 3, Prostate Cancer-associated Protein 6, SLC45A3, PCANAP6, PRST, IPCA-2, IPCA6, IPCA-6, IPCA-8) (Biotin)
Sign In for Pricing
View Details MBS6401826-02 5x 0.1 mL
Prostein (Solute Carrier Family 45 Member 3, Prostate Cancer-associated Protein 6, SLC45A3, PCANAP6, PRST, IPCA-2, IPCA6, IPCA-6, IPCA-8) (Biotin)
Sign In for Pricing
View Details