ITK degrader 1
Product Specifications
Target
Others, PROTACs, Tyrosine Kinases
Related Pathways
Tyrosine Kinase/Adaptors, PROTAC, Others
Bioactivity
ITK Degrader 1, a highly selective interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice) degrader, induces rapid and prolonged degradation of ITK and effectively suppresses IL-2 secretion (EC50=35.2 nM, Jurkat cells) stimulated by anti-CD3 antibody in vivo. Additionally, it demonstrates favorable plasma exposure levels [1].
Molecular Formula
C48H57F3N10O7
Molecular Weight
943.02
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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